Collagen or whey? What about both? We stacked up collagen vs. whey, and I’ll tell you now, the results were unexpected!
What you’ll learn:
Collagen powder is a newly popular protein with research to back up its use for moisturizing skin, strengthening hair and nails, weight loss, joint pain, exercise, recovery, and more!
To take a bird’s eye view of supplementing with collagen: pretty much anything that has to do with your connective tissue can be improved with a collagen supplement. I know that’s a pretty grandiose statement, but hear me out - logically it makes sense and the research backs it up.
Collagen is essentially the “glue” that holds everything in your body together. So if you think about it, the health of your collagen has a lot to do with the health of you!
Collagen protein is different from other proteins because it has a higher content of certain amino acids. Glycine, proline, and hydroxyproline are the major amino acids in collagen, but most others (besides tryptophan) are there as well, just in smaller amounts.
Here’s a chart showing the amount of individual amino acids in Resync’s collagen protein. You can see that the collagen-supporting amino acids glycine, proline, hydroxyproline, and hydroxylysine are very high in our collagen supplement.
Collagen protein is also pretty high in arginine, which has immune supporting and healing properties.
The benefits of collagen go beyond its individual amino acids though. The sum of the parts is greater than the whole in this case.
When you eat a hydrolyzed collagen protein, some of the collagen is broken down to amino acids and some of it stays in larger protein form. Although it’s hard to study what happens to those unique proteins, it appears that mammals can shuttle them to where they need to go - your joints and tendons, for example.
Besides providing the crucial building blocks, these small proteins also seem to have an anti-inflammatory effect, specifically on your body’s collagen-making machinery. This is one reason why collagen peptides may be so great for reducing the painful symptoms of inflammatory joint issues.
No other protein powder has been shown to have these kinds of anti-inflammatory effects.
These specific amino acids and proteins - plus a good source of vitamin C, a bit of copper and a healthy amount of iron - are critical for your body to make collagen. But if your body can make all these amino acids itself, do you even have to supplement with them?
Technically, no, you don’t have to supplement with collagen to make collagen. But there are a few reasons you might want to look a bit closer:
Supplementing with collagen has been shown to increase the integrity of all of your connective tissue. So it’s up to you to keep your skin glowing and your joints and bones healthy as you age.
Some experts suggest that some of the chronic diseases we’re looking at nowadays may be caused, in part, by the lack of connective tissues in our diet. The amino acids glycine and proline have been highlighted for the possibility that they might be limiting factors in our overall health!
I mean, when was the last time you chewed on the end of a bone, or made bone broth for every meal during the winter months? Choose a quality collagen supplement and you won’t have to spend hours making your own bone broth.
Do you have trouble sleeping? Glycine - which is very high in collagen - might be helpful for that!
Do you have osteoarthritic joint pain? Study on study shows that collagen can help!
What about joint pain when you exercise? Supplementing with collagen can be helpful for that, too!
Wrinkles around your eyes? Dry skin? Brittle hair or nails? The research is still coming out, but so far, multiple studies have shown promising results!
So whether or not your body can make collagen on its own, or if we should or should not be eating more connective tissue, simply look at the science-backed benefits and tell me you don’t want to be optimizing your health with a collagen supplement!
I’ll rest my case: from research to clinical experience to logical reasoning, no matter how you slice it, collagen can be an important, and often lacking, piece of our diet.
Every protein supplement has different levels of amino acids, making them best for certain uses. Each is digested differently, meaning you have to pay attention to the timing of your protein shake.
It might seem complicated, but what you need to know about whey protein doesn’t have to be.
When milk is processed to make cheese, it separates into two major protein sources: casein and whey.
Whey protein is high in branched-chain amino acids that your muscles burn for as well as lysine, critical for muscle growth. The high levels of these amino acids is what makes whey an attractive choice for maximizing gains from your workout.
Just as collagen is ideal for supporting connective tissue, whey - being high in lysine, leucine, isoleucine, and valine - is ideal for supporting muscle tissue. Notably, whey is not very high in amino acids that support connective tissue health.
Two studies, one using whey, casein, or soy in healthy young men and another comparing whey to casein in older adults, show that, for muscle protein synthesis (the technical term for microscopic muscle growth) whey is better than soy, and soy is better than casein.
Zoom out to the macro level and you’ll see that whey doesn’t necessarily create any greater advantage in your average person who’s trying to get to the gym more.
One study showed that whether it’s leucine, soy, whey, or just plain calories from carbohydrates, the biggest part of gaining muscle is to get enough calories first. After you’ve got that base covered, then you might consider how whey protein can stimulate muscle cells more than other types of protein.
Most studies take advantage of the fast-digesting nature of whey by using it after a workout.
Since whey is digested quickly, that means that there may be better options for muscle support overnight (you’ll want to pick a slow digesting protein like casein.
So what is the best way to use whey? Some research shows that getting a large amount all at once may be better than spreading out your protein shake.
That being said, you can’t absorb more than about 20 grams of protein in a single sitting, so spread your protein throughout the day.
Or to be more technical, you can only absorb a max of about 0.4 grams of protein per kilogram body weight per meal. Depending on your weight, that might be 20 grams, or it could be around 30 grams. The takeaway here is to get adequate protein in every meal if you’re trying to maximize your benefits.
For muscle protein synthesis:
Whey > Soy > Casein
Consume whey protein throughout the day in 20 gram servings.
To gain the most strength and to be resilient against injury, though, you’re going to have to look beyond how your muscles look.
How are you supporting your entire musculoskeletal system?
Are you getting a protein supplement that’s specifically tailored to support the connective tissue, the collagen that connects your muscles to your bones?
In a similar way that whey is ideal for promoting muscle strength, collagen is ideal for supporting tendon, ligament, and joint strength.
To illustrate the difference between collagen and whey protein, take a look at this table. The amino acid content in Resync Your Joints - Collagen Blend is compared head-to-head with the amino acids in a typical whey protein (note that we got the tryptophan content from another source since it’s not typically reported).
Note that every batch of whey protein varies considerably! These numbers are representative, but probably don’t match up with the whey you might be taking.
With whey being great for muscle building, and collagen being the go-to for joints and skin, can you combine them and get the benefits of both?
Let’s stack the graphs I showed you earlier to see what happens.
That’s more like it! You can see that the two protein sources complement each other nicely, giving you all the essential and nonessential amino acids you need for total body health:
Add in the unique biofunctional, anti-inflammatory properties of collagen to the mix and you’ve got a winning combination! There are a number of benefits shared by both, so you won’t be losing anything by mixing the two:
If both proteins have been shown to be so favorable for all kinds of issues, why not take them both and have all your bases covered?
The takeaways from this post:
If you want to dive deep into all the reasons why collagen is a must-have for your routine, try out a bottle of our collagen and we’ll give you a free copy of our ebooks: “The Best Strategies to Resync your Performance and Recovery with Collagen” and “7 Drinks To Change How You Feel, Look and Perform”.
If you want to know which collagen powder to buy, what different certifications mean, and what products return the best results, check out our buyers guide here:
But if you’re ready to do the work yourself, examining every product label in the supplement aisle, here’s our guide on how to choose the best collagen supplement:
You already know that Resync is one of the highest quality, most well-tested products out there, and now you know why Resync Collagen Blend is so good for looking good on the outside!
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While some companies try to sell you stuff with clickbait and fake news, we make sure to back up our claims with hard data. We believe that when you have the right information, you’re empowered to make the best decision for yourself. That’s why we break down the complex science of nutrition and supplements into practical takeaways you can use today.
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Alexander, J. Wesley, and Dorothy M. Supp. “Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection.” Advances in Wound Care, vol. 3, no. 11, Nov. 2014, pp. 682–90. PubMed Central, doi:10.1089/wound.2013.0469.
Almeida, Cristine C., et al. “Protein and Amino Acid Profiles of Different Whey Protein Supplements.” Journal of Dietary Supplements, vol. 13, no. 3, May 2016, pp. 313–23. Taylor and Francis+NEJM, doi:10.3109/19390211.2015.1036187.
Barbul, Adrian. "Proline Precursors To Sustain Mammalian Collagen Synthesis". The Journal Of Nutrition, vol 138, no. 10, 2008, pp. 2021S-2024S. Oxford University Press (OUP), doi:10.1093/jn/138.10.2021s.
Burd, Nicholas A., et al. “Greater Stimulation of Myofibrillar Protein Synthesis with Ingestion of Whey Protein Isolate v. Micellar Casein at Rest and after Resistance Exercise in Elderly Men.” British Journal of Nutrition, vol. 108, no. 6, Sept. 2012, pp. 958–62. Cambridge Core, doi:10.1017/S0007114511006271.
Castelo-Branco, Camil et al. "Relationship Between Skin Collagen And Bone Changes During Aging". Maturitas, vol 18, no. 3, 1994, pp. 199-206. Elsevier BV, doi:10.1016/0378-5122(94)90126-0.
Choi F, et al. "Oral Collagen Supplementation: A Systematic Review of Dermatological Applications." Journal of Drugs in Dermatology, vol. 18, no. 1, Jan 2019, pp. 9-16, doi:
Dressler, Patrick, et al. “Improvement of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability.” Journal of Sports Science & Medicine, vol. 17, no. 2, May 2018, pp. 298–304.
García-Coronado, Juan Mario, et al. “Effect of Collagen Supplementation on Osteoarthritis Symptoms: A Meta-Analysis of Randomized Placebo-Controlled Trials.” International Orthopaedics, vol. 43, no. 3, Mar. 2019, pp. 531–38. Springer Link, doi:10.1007/s00264-018-4211-5.
Jendricke, Patrick, et al. “Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial.” Nutrients, vol. 11, no. 4, Apr. 2019, p. 892. www.mdpi.com, doi:10.3390/nu11040892.
König, Daniel et al. "Specific Collagen Peptides Improve Bone Mineral Density And Bone Markers In Postmenopausal Women—A Randomized Controlled Study". Nutrients, vol 10, no. 1, 2018, p. 97. MDPI AG, doi:10.3390/nu10010097.
Layman, Donald K., et al. “Applications for α-Lactalbumin in Human Nutrition.” Nutrition Reviews, vol. 76, no. 6, June 2018, pp. 444–60. PubMed Central, doi:10.1093/nutrit/nuy004.
Naidoo, K., et al. “Understanding the Amino Acid Profile of Whey Protein Products.” Global Journal of Health Science, vol. 10, no. 9, Aug. 2018, p. 45. DOI.org (Crossref), doi:10.5539/gjhs.v10n9p45.
Meléndez-Hevia, Enrique, et al. “A Weak Link in Metabolism: The Metabolic Capacity for Glycine Biosynthesis Does Not Satisfy the Need for Collagen Synthesis.” Journal of Biosciences, vol. 34, no. 6, Dec. 2009, pp. 853–72. doi:10.1007/s12038-009-0100-9.
Mobley, C. Brooks, et al. “Effects of Whey, Soy or Leucine Supplementation with 12 Weeks of Resistance Training on Strength, Body Composition, and Skeletal Muscle and Adipose Tissue Histological Attributes in College-Aged Males.” Nutrients, vol. 9, no. 9, Sept. 2017, p. 972. www.mdpi.com, doi:10.3390/nu9090972.
Oesser, Steffen et al. "Oral Administration Of 14C Labeled Gelatin Hydrolysate Leads To An Accumulation Of Radioactivity In Cartilage Of Mice (C57/BL)". The Journal Of Nutrition, vol 129, no. 10, 1999, pp. 1891-1895. Oxford University Press (OUP), doi:10.1093/jn/129.10.1891.
Schoenfeld, Brad Jon, and Alan Albert Aragon. “How Much Protein Can the Body Use in a Single Meal for Muscle-Building? Implications for Daily Protein Distribution.” Journal of the International Society of Sports Nutrition, vol. 15, Feb. 2018. PubMed Central, doi:10.1186/s12970-018-0215-1.
Sousa, Gabriela T. D., et al. “Dietary Whey Protein Lessens Several Risk Factors for Metabolic Diseases: A Review.” Lipids in Health and Disease, vol. 11, July 2012, p. 67. PubMed, doi:10.1186/1476-511X-11-67.
Tang, Jason E., et al. “Ingestion of Whey Hydrolysate, Casein, or Soy Protein Isolate: Effects on Mixed Muscle Protein Synthesis at Rest and Following Resistance Exercise in Young Men.” Journal of Applied Physiology, vol. 107, no. 3, Sept. 2009, pp. 987–92. journals.physiology.org (Atypon), doi:10.1152/japplphysiol.00076.2009.
Veldhorst MA, Nieuwenhuizen AG, Hochstenbach-Waelen A, Westerterp KR, Engelen MP, Brummer RJ, Deutz NE, Westerterp-Plantenga MS. A breakfast with alpha-lactalbumin, gelatin, or gelatin+ TRP lowers energy intake at lunch compared with a breakfast with casein, soy, whey, or whey-GMP. Clin Nutr. 2009 Apr;28(2):147-55.
West, Daniel WD, et al. “Rapid Aminoacidemia Enhances Myofibrillar Protein Synthesis and Anabolic Intramuscular Signaling Responses after Resistance Exercise–.” The American Journal of Clinical Nutrition, vol. 94, no. 3, Sept. 2011, pp. 795–803. academic.oup.com, doi:10.3945/ajcn.111.013722.
Wirunsawana, Kamonkiat, and Sikarin Upala. “Impact of Whey Protein on Bone Mineral Density: A Systemic Review and Meta-Analysis.” Journal of Clinical Densitometry, vol. 21, no. 4, Oct. 2018, pp. 597–98. ScienceDirect, doi:10.1016/j.jocd.2018.05.005.
Wirunsawanya, Kamonkiat, et al. “Whey Protein Supplementation Improves Body Composition and Cardiovascular Risk Factors in Overweight and Obese Patients: A Systematic Review and Meta-Analysis.” Journal of the American College of Nutrition, vol. 37, no. 1, 2018, pp. 60–70. PubMed, doi:10.1080/07315724.2017.1344591.
Yamadera, Wataru, et al. “Glycine Ingestion Improves Subjective Sleep Quality in Human Volunteers, Correlating with Polysomnographic Changes.” Sleep and Biological Rhythms, vol. 5, no. 2, Apr. 2007, pp. 126–31. onlinelibrary.wiley.com, doi:10.1111/j.1479-8425.2007.00262.x.
Zhu, Ping, et al. “Oral Administration of Type-II Collagen Peptide 250–270 Suppresses Specific Cellular and Humoral Immune Response in Collagen-Induced Arthritis.” Clinical Immunology, vol. 122, no. 1, Jan. 2007, pp. 75–84. ScienceDirect, doi:10.1016/j.clim.2006.08.004.