What is Nitric Oxide (N-O)?

Nitric oxide is an essential molecule to your health, energy and daily vitality. It plays a key role in the regulation of numerous vital biological functions.

Nitric oxide (N-O) is a naturally occurring gas that transmits signals in your body. Even though it may be abundant in a healthy young body, unfortunately, it has a short half-life (it is very unstable), and needs to be replenished on a regular basis.

It supports many essential reactions underneath your skin, which you may not even pay attention to, but that you need to simply exist, regardless of your age.

Perhaps most famously (at least amongst scientists and nutritionists), nitric oxide is known for being a vasodilator, but what does that mean to you?

As a vasodilator, nitric oxide has the potential to relax and widen your blood vessels, allowing for more effective and efficient blood flow, nutrient delivery, and better oxygenation throughout the body.

All in all, nitric oxide supports you to keep your body flowing with energy!

Science and history

Resync is not the first to share with you scientific data on this “miracle molecule”. Four separate fields of research –toxicology, immunology, cardiovascular pharmacology, and neurobiology –converged to focus their efforts on nitric oxide. This merge led to the discovery of its biosynthesis and wide-ranging role as a messenger and effector molecule which led to the awarding of the Nobel Prize.

The Nobel Prize in Physiology or Medicine in 1998 was won by Robert F. Furchgott, Louis J. Ignarro and Ferid Murad “for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular system”.

Resync CEO, Barbara Depta, had the pleasure and honor to meet, and learn from the two Nobel Prize winners Louis J. Ignarro and Ferid Murad at the Nitric Oxide International Society Event in Oxford in 2018.

Both Lou Ignarro and Ferid Murad, spoke about the field of nitric oxide research and how much it has developed since the discovery of endogenous nitric oxide in 1986. They emphasized research publications in a variety of areas in biology and medicine, and excited everyone on the ongoing numerous therapies that have been and will continue to be developed.

This research allows Resync to utilize the scientific data, continue the research with clinical protocols, and provide the public with clean and valuable products to support nitric oxide levels and daily vitality.

Why N-O levels drop and how to replenish them 


We already know that as we age, our connective tissue loses pliability, which results in less range of motion. On top of that, our energy levels and nitric oxide decreases as well.

We know these natural aging processes cannot be reversed. But the good news is, they can be positively influenced by a targeted diet supported with nutritional supplements based on natural nitrates and antioxidants just like the ingredients in Resync products.

By the time we reach 40 years of age, research has shown that we only produce about half or even less of the nitric oxide we produced when we were 20. Unfortunately, nitric oxide production only continues to decline as we age beyond that.It is also important to note that the effects of aging on nitric oxide production varies between men and women. By the age of 40, men produce about 50% of the nitric oxide they did in their teens and twenties. Women only produce about 35% of what they did in their twenties at age 40.

As you can see, it is essential for us to consume healthy dietary sources of natural nitrates to help support nitric oxide levels as we age, which in turn can help promote our health and daily vitality.


As you learned when reading about the decrease of nitric oxide production as we age, what we eat and put into our body also has a huge effect on nitric oxide production. We can use this to our advantage by eating proper ingredients (not just a healthy diet) to promote nitric oxide. However, a large majority of people tend to have a dietary insufficiency of green leafy vegetables and red veggies which only exacerbates the issue.

What does this mean?

You do need to pay attention to your daily diet to stay on top of N-O bioavailability in your body. The more nitrates you consume, the more likely you are to generate more nitric oxide in your body!

You can find dietary nitrates in many foods. Typically, you’ll find them in leafy green vegetables and some reds as well but the levels of nitrates vary heavily between different veggies. On top of that, the origin of harvesting, the soil condition, and the way the vegetable is processed (into juice, concentrate, powder or extract) all have an effect on the nitrate levels in that ingredient. Beets, for example, are very inconsistent in nature –so much so that they difficult to standardize to an exact nitrate level. Of the veggies that produce nitrates, they are also heavy in sugar and lower in nitrate content when compared to an extract derived from red spinach vegetable. As you can see on the graph to the right, the nitrate levels present in red spinach, the primary ingredient in Resync, are among the highest of all veggies. Resync products are also filled with additional nitric oxide precursors from natural nitrates, like red beet and combined with powerful antioxidant ingredients, like aronia berry, turmeric, ginger and mango extract.

The US population does not eat enough vegetables in the first place. On top of that, of the veggies that we do consumer here in the US, most of them aren’t the ones high in natural nitrates. See the below chart compiled by R.M. Keller, M.C. Prater, L.M. Beaver, and N.G. Hord of Oregon State university for an example of nitrate concentration between different cultural meal patterns. 

Today we know nitrates are metabolized to nitric oxide in the human body by oral nitrite-reducing bacteria. That is why consuming specific veggies on a regular basis can only support your nitric oxide levels in your body.  

Antiseptic Mouthwash

Research has shown that people who use antiseptic mouthwash can destroy the good bacteria in the mouth that are responsible for the reduction of nitrates into nitrite and then to nitric oxide. You do not want to kill bacteria, which is essential to your health. Keeping your mouth hygiene intact does not need to involve sterilizing your mouth with antibacterial mouthwash. Protecting your oral microbiome is important.

New research conducted by Gena D Tribble and the faculty and staff of the UTHealth School of Dentistry in Houston, TX and Baylor College of Medicine on oral microbiome and oral health habits addresses that “[t]he oral microbiome has the potential to provide an important metabolic function in human blood pressure physiology by contributing to the generation of nitric oxide”. They also state that “frequency of tongue cleaning [i]s the only behavioral variable with a significant association to bacterial community composition and metabolic activity, with daily tongue cleaning significantly increasing the nitrates reducing bacterial content of the tongue microbiome. The study concludes that “[e]fforts to improve the enterosalivary circulation of nitrate should consider oral health and hygiene in addition to dietary measures”.

What might this mean?

The absence of these bacteria may contribute to lower N-O levels in your body. Eat dietary natural nitrates and perhaps clean your tongue to support your daily vitality and nitric oxide production.


Physical activity/exercise is one of the easiest ways to stimulate nitric oxide in your body and support your cardiovascular health. However, with a sedentary lifestyle, we lose the ability to generate nitric oxide. As an outcome, the enzyme (eNOS) that supports our heart health and nitric oxide levels in response to exercise becomes dysfunctional. This typically leads to nitric oxide insufficiency.

Recent studies also show that well-exercised muscles can become hypoxic and acidic. That’s one of many reasons why dietary natural nitrates and antioxidants like those found in Resync could absolutely combat those challenges and support your muscle recovery.

Add consistency to your energy just like many professional, collegiate, and recreational athletes do and decrease the gap between tired and ready to go with Resync products.

With natural nitrates you can benefit from circulation support which in turn can affect your stamina and cognition as well. Your body truly deserves the best high-quality products to support your nitric oxide production, and on top of that, to support healthy inflammatory response post any physical activity.

Resync products were created with you in mind. Consume Resync safely and confidently and enjoy the results that will come your way.

These are the vegetables high in natural nitrates. You can find red spinach and beets in Resync!


10th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide. Oxford, UK, 2018.

Gallardo, EJ, and AR Coggan. “What's in Your Beet Juice? Nitrate and Nitrite Content of Beet Juice Products Marketed to Athletes.” IUPUI, 2018. https://www.ncbi.nlm.nih.gov/pubmed/30299195